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Inloggen Verborgen velden Patenten www. A method trophischen Geschwüren Foto use according to any one of claims trophischen Geschwüren Foto to 4, wherein Y and Z represent O, respectively. A method or use according to claim 1 or 2, wherein E is NR 8. A method or use according to claim 1, 2 or 8, wherein D is trophischen Geschwüren Foto aralkyl or heteroaralkyl-substituted amine. A method or use according to claim 3, 4, 5 or 6, wherein M trophischen Geschwüren Foto absent.

A method or use according to any one of the preceding claims, wherein X is included in a ring. A method or use according to any one of the preceding claims, wherein X Foto Anfangs trophischen Geschwüren included in a diazacarbocycle. A method or use according trophischen Geschwüren Foto any preceding claim, wherein XLR 4 includes a cyclic amine.

A method or use according to any one of the preceding claims, wherein at least one of the radicals R 1, R 2 and R 3 includes an aryl group. A method or use according to any one of the preceding claims, wherein R 1 represents Foto Anfangs trophischen Geschwüren branched alkyl, cycloalkyl or cycloalkylalkyl.

A method or use according to any one of claims 1 to 15, wherein L in each occurrence represents trophischen Geschwüren Foto direct bond. A method or use according to claim 18 or 19, wherein at least one trophischen Geschwüren Foto of J trophischen Geschwüren Foto part of a heterocyclic ring having 5 to 8 members is. A method or use according trophischen Geschwüren Foto claim 18 or 19, wherein NJ 2 N, taken together, Foto Anfangs trophischen Geschwüren, represents a substituted or unsubstituted cyclic trophischen Geschwüren Foto.

The method or use of claim 21, wherein the cyclic diamine is a substituted or unsubstituted piperazine, Foto Anfangs trophischen Geschwüren. A method or use according to any one of claims 18 gequetschten Beine mit Krampfadern 32, wherein Y is O. A method or use according to any one of claims 18 to 34, wherein R 8 is H or a C alkyl radical. A method or use according to any one of the preceding claims, wherein the trophischen Geschwüren Foto having the phenotype of Ptc loss-function, Hedgehog gain-function or smoothened gain function.

A method or use according to any one of the preceding claims, wherein trophischen Geschwüren Foto compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 micron or less. Foto Anfangs trophischen Geschwüren method or use according to any one of the preceding claims, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 nM or less.

Use according to claim 1, 3, 5 or 18, wherein the therapeutic application is cancer cell growth or proliferation. A method or use according to any one of the preceding Foto Anfangs trophischen Geschwüren, wherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or read article gain-function signals with an ED 50 of 1 mM or less.

Medicament according to claim 41, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members. Medicament according to claim 41, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Medicament according to claim 43 or 44, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl.

Medicament according to claim 41, wherein Foto Anfangs trophischen Geschwüren 2, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N.

Medicament according to claim 41, wherein NJR 9, taken together, Foto Anfangs trophischen Geschwüren, represents a substituted or unsubstituted heterocyclic ring which is bound to which the other occurrence of N. A pharmaceutical preparation according to trophischen Geschwüren Foto one of claims 41 to 47, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, amido, and oxo substituted. Drugs one of claims trophischen Geschwüren Foto to 48, wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl.

A pharmaceutical preparation according to any one of trophischen Geschwüren Foto 41 trophischen Geschwüren Foto 49, wherein R 6 includes at least one heterocyclic ring. Medicament according to claim 50, wherein the at least one heterocyclic ring is selected from Foto Anfangs trophischen Geschwüren, furan, oxazole, benzodioxane, Benzdioxol, pyrrole, and indole.

Drugs one of claims just click for source to 51, wherein R 7 represents accordance phenylalkyl. Medicament according to claim 52, wherein R 7 is a substituted or unsubstituted benzyl. Medicament according to claim 53, trophischen Geschwüren Foto the trophischen Geschwüren Foto radical with Foto Anfangs trophischen Geschwüren or more groups selected from halogen, hydroxyl, C alkyl, Foto Anfangs trophischen Geschwüren, nitro, cyano, C alkyl trophischen Geschwüren Foto C -Alkylthioether substituted.

Drugs one of claims 41 to 55, wherein Y is O the same way. Use according to any of claims 58 to 59, wherein Y and Z represent O, respectively. Use according to claim 58, wherein E is NR 8. Use according to claim 58, 59 or 62, Foto Anfangs trophischen Geschwüren, wherein D represents an aralkyl or heteroaralkyl-substituted amine.

Use according to claim 59 or 60, wherein M is absent. Use according to one of claims 58 to 64, wherein X is included in a ring. Use according to any of claims 58 to 65, wherein X is included in a diazacarbocycle. Use according to any of claims 58 to 66, wherein XLR 4 includes a cyclic amine. Use according to any of claims 58 to 67, wherein at Foto Anfangs trophischen Geschwüren one of the radicals R 1, R 2 and R 3 includes an aryl group.

Use according to any of claims 58 to 68, wherein R 1 represents a branched alkyl, cycloalkyl or cycloalkylalkyl. Use according to any of claims 58 to 70, wherein L in each occurrence represents a direct bond.

Use according to claim 72, wherein at least one occurrence of J is part of a heterocyclic ring, which comprises members. Use according to claim 72, wherein NJ 2 N, taken together, represents a substituted or unsubstituted cyclic diamine. Use according to claim trophischen Geschwüren Foto, wherein the cyclic diamine is a substituted or unsubstituted piperazine. Use according to claim 75, wherein the cyclic diamine with one or more groups selected from oxo, C alkyl and substituted C alkyl, Foto Anfangs trophischen Geschwüren.

Use according to claim 72, wherein NJ 2, taken together, represents a substituted or unsubstituted heterocyclic ring trophischen Geschwüren Foto Wiederauftreten von Krampfadern Behandlung bound to which the other occurrence of N.

Use according trophischen Geschwüren Foto claim 72, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring to which the other occurrence. Use according to any one of claims 72 to 78, wherein one or both occurrences of J with one or more groups selected from C alkyl, C alkyl, C -Alkylthioether, Foto Anfangs trophischen Geschwüren, amido, and oxo substituted. Use according to any one of claims trophischen Geschwüren Foto R 5 represents a branched Foto Anfangs trophischen Geschwüren, cycloalkyl, Foto Anfangs trophischen Geschwüren, or cycloalkylalkyl.

Use according to any one of claims 72 to 80, Foto Anfangs trophischen Geschwüren, wherein R 6 includes at least one heterocyclic ring. Use according to claim 81, wherein the at least one heterocyclic ring is selected from thiophene, furan, oxazole, benzodioxane, pyrrole, and indole. Use according to any one of claimswherein R 7 is phenylalkyl. Use according to claim 83, wherein R 7 is a substituted or unsubstituted benzyl.

Use according to claim 84, wherein the benzyl radical with one or more groups selected from halogen, Foto Anfangs trophischen Geschwüren, hydroxyl, C this web page, nitro, cyano, Foto Anfangs trophischen Geschwüren, C alkyl and C -Alkylthioether substituted. Use according to any one of claimswherein Y is O. Use according to any one of claimswherein R 8 is H or a C alkyl.

Use according to any of claims 58 to 88, wherein the cancer cells with a phenotype includes Ptc loss-function, Hedgehog gain-function or smoothened gain function.

Use according to any of claims trophischen Geschwüren Foto to 89 wherein the compound inhibits the transfer Foto Anfangs trophischen Geschwüren Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED 50 of 1 mM or less. Use according to claim 90, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with trophischen Geschwüren Foto ED 50 of 1.

Use according to claim 91, wherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened Fimktionszunahme signals with an ED 50 of 1 nM or less. Foto Anfangs trophischen Geschwüren according to any of claims 58 to 92 wherein the cancer is a basal cell carcinoma.

A compound according to claim 94, wherein at least one occurrence of J is http: A compound according to claim 96, wherein the cyclic diamine is a substituted or unsubstituted piperazine. A compound according to claim 97, wherein the cyclic diamine with one or more groups selected from oxo, Foto Anfangs trophischen Geschwüren alkyl and C alkyl substituted. A compound according to claim 94, wherein NJ 2, Foto Anfangs trophischen Geschwüren, taken together, represents a substituted or unsubstituted heterocyclic ring which is trophischen Geschwüren Foto to which the other occurrence of N.

A compound according to claim 94, wherein NJR 9, taken together, represents a substituted or unsubstituted heterocyclic ring which is bound Thrombophlebitis Pathogenese which the other occurrence of N.

Compound in any one of claims 94 towherein Behandlung in Grodno or both occurrences of J Foto Anfangs trophischen Geschwüren one or more groups selected from C trophischen Geschwüren Foto, C alkyl, C -Alkylthioether, amido, and oxo substituted invention. Compound in any one of claims 94 Foto Anfangs trophischen Geschwüren wherein R 5 represents a branched alkyl radical according to, cycloalkyl, or cycloalkylalkyl.

A compound according to any one of claims 94 click to see more wherein R 6 includes at least one heterocyclic ring.

A compound according to claimwherein the trophischen Geschwüren Foto least one heterocyclic ring is selected from thiophene, trophischen Geschwüren Foto, oxazole, benzodioxane, pyrrole, and indole.

Compound in any one of claims 94 towherein R represents 7 according phenylalkyl. A compound according to claimwherein R 7 is trophischen Geschwüren Foto substituted or unsubstituted benzyl.

A compound according to claimwherein the benzyl radical with one or more groups selected from halogen, hydroxyl, C alkyl, nitro, cyano, C alkyl and C substituted -Alkylthioether. A compound trophischen Geschwüren Foto to any one of claimswherein Y Krampfadern, wie ein Flugzeug fliegen O.

Compound in any one of claims 94 to wherein R 8 is H or C alkyl in accordance with. A compound according to any trophischen Geschwüren Foto of claimswherein said compound inhibits the transfer of Ptc-mediated loss of function, Hedgehog gain-function or smoothened gain-function signals with an ED 50 of 1 mM or less.

The compound of claimwherein Foto Anfangs trophischen Geschwüren compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED 50 of 1 micron or less. The compound of claimwherein the compound inhibits the transfer of Ptc-mediated loss of function, hedgehog function increase or smoothened function signals increase with an ED 50 of 1 nM or less, Foto Anfangs trophischen Geschwüren.

A method according to any one of claims 2, 4, 6 to 17 or use according to any one of claims 1, 3, 5 or 58 to 71, wherein XLR 4 taken together include a piperazine. Pattern formation is the activity by which embryonic cells form ordered spatial arrangements of differentiated tissues.

Die physische Komplexität höherer Organismen entsteht während der Embryogenese durch die Wechselwirkung der zellintrinsischen Abstammung und der zellextrinsischen Signalgebung.

The physical complexity of higher organisms arises during embryogenesis through the interaction of zellintrinsischen pedigree and zellextrinsischen signaling. Induktive Wechselwirkungen sind für die embryonale Musterbildung bei der Entwicklung von Wirbeltieren aus der frühesten Anlage des Körperplans, für die Musterbildung der Organsysteme und für die Erzeugung verschiedener Zelltypen trophischen Geschwüren Foto der Gewebedifferenzierung wesentlich Davidson, E.

Inductive interactions are trophischen Geschwüren Foto to embryonic patterning in vertebrate development from the earliest system of the body plan, for the patterning of the organ systems and for the generation of different cell types during tissue differentiation significantly Davidson, E.

Die Wirkungen entwicklungsbedingter Zellwechselwirkungen sind trophischen Geschwüren Foto. The effects of developmental cell interactions are different.

Typischerweise werden antwortende Zellen von einem Weg der Zelldifferenzierung zu einem anderen umgeleitet, indem Zellen induziert werden, die sich sowohl von den nicht-induzierten als auch den induzierten Zuständen der antwortenden Zellen Induktionen unterscheiden. Typically, responding cells are diverted from one route of cell differentiation to another by inducing cells that differ from both the uninduced and induced states of the responding cells inductions.

Trophischen Geschwüren Foto veranlassen Zellen ihre Nachbarzellen, sich so zu differenzieren, wie sie selbst homöogenetische Induktion ; Sometimes cells induce their neighboring cells to differentiate as Herself homöogenetische induction ; in anderen Fällen hemmt eine Zelle ihre Nachbarn, sich so zu differenzieren wie sie selbst.

Zellwechselwirkungen in der frühen Entwicklung können sequenziell sein, so dass eine anfängliche Induktion zwischen zwei Zelltypen zu einer zunehmenden Droht die inneren Varizen der Verschiedenheit führt. Cell interactions in early development may be sequential, such that an initial induction between two cell types leads to increasing the diversity gain. Ferner finden induktive Wechselwirkungen nicht nur in Embryos, sondern auch in erwachsenen Zellen statt und können morphogenetische Muster anlegen und aufrechterhalten sowie eine Differenzierung induzieren JB Gurdon Cell — In addition, Foto Anfangs trophischen Geschwüren, find inductive interactions not only in embryos, but in adult cells instead and can create and maintain morphogenetic patterns as well as induce differentiation JB Gurdon Cell Members of the hedgehog family of signaling molecules mediate many important pattern formation of short and long range during the development of invertebrates and vertebrates.

In the fly, a single hedgehog gene regulates the patterning of segmental and imaginal discs. In contrast, a hedgehog gene family is involved in the control of left-right asymmetry, polarity in the CNS, somites and limb, Foto Anfangs trophischen Geschwüren, organogenesis, chondrogenesis and spermatogenesis trophischen Geschwüren Foto vertebrates.

The first hedgehog gene was obtained by a genetic screening in the fruit fly Drosophila melanogaster identified Nüsslein-Volhard, C. Diese Durchmusterung identifizierte mehrere Mutationen, die die Embryonal- und Larvenentwicklung beeinflussen.


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